Bacterial thiol oxidoreductases — from basic research to new antibacterial strategies

New antibacterial therapeutics and strategies.

Studies on new antibacterial therapeutics and strategies are currently being conducted in many microbiological, pharmaceutical and biochemical laboratories. The antibacterial activity of plant-derived compounds as well as silver and gold nanoparticles is the subject of this minireview. The application of photodynamic therapy is also discussed.

University of Groningen Thiol - disulfide oxidoreductases in Bacillus subtilis

New strategies to fight bacterial adhesion

Initial adhesion of bacteria to biomaterials' surface is assumed to be an important stage in their colonization which may to lead to severe infections and loss of medical devices. Thus, the knowledge of how these microorganisms adhere and which factors affect this phenomenon proves to be of great importance in order to avoid their colonization. Hydrophobicity, charge, roughness and chemical com...

Functional analysis of paralogous thiol-disulfide oxidoreductases in Bacillus subtilis.

The in vivo formation of disulfide bonds, which is critical for the stability and/or activity of many proteins, is catalyzed by thiol-disulfide oxidoreductases. In the present studies, we show that the Gram-positive eubacterium Bacillus subtilis contains three genes, denoted bdbA, bdbB, and bdbC, for thiol-disulfide oxidoreductases. Escherichia coli alkaline phosphatase, containing two disulfid...

Noninvasive Strategies to Optimise Brain Plasticity: From Basic Research to Clinical Perspectives

Brain plasticity can be defined as the capacity of cerebral neu-rons and neural circuits to change, structurally and functionally , in response to experience. This fundamental property is essential for maturation of sensory functions during development , for the adaptability of our behaviour to the environment through learning and memory processes and for brain repair in response to disease and...